Biohacker Review: The Caviar of Russian Nootropics
I've been researching Russian Nootropics and with Semax, more than any other Nootropic ingredient I've researched, I kept coming across Biohackers saying that it's the best smart drug they've ever tried.
Semax is a heptapeptide, synthetic analog of an ACTH(4-10) fragment of adrenocorticotropic hormone. It has a wide spectrum of actions, and at the same time, lacks hormonal activity and side effects. As a nootropic, Semax improves the processes associated with memory formation and learning. As an anxiolytic, Semax increases the levels of serotonin and dopamine in the brain thus achieving a balanced and stable mood. As a neuroprotector, Semax helps to reduce damaged cells caused by oxidative stress, provides positive effect on cerebral blood flow, increases resistance to hypoxia, prevents and reduces brain damage caused by stroke. As a neurotropic Semax stimulates the growth and survival of developing neurons as well as maintenance of mature neurons thus increasing the expression of neurotrophins in messenger RNA (Ribonucleic acid) and protein levels. Semax has curative properties against glaucoma optic neuropathy, optic nerve atrophy and diabetic neuropathy, as well as peptic ulcer.
Further read: https://bodyhunter.cc/semax/
PACKAGING & DOSAGE
- MORE INFO
- N-acetyl semax amidate is a heptapeptide developed in Russia to treat stroke, optic nerve disease, peptic ulcer, boost the immune system, treat brain damage following insomnia, and other cognitive disorders. Semax is what’s called a synthetic heptapeptide. In other words, it’s a chain of seven distinct amino acids formed as a single molecule. Interestingly, it’s an analog of adrenocorticotropic hormone 4-10 (ACTH) which is released by the pituitary glands in response to surrounding stress. However, while the natural ACTH 4-10 hormone is degraded to amino acids while in the blood stream, n-acetyl semax is broken down to a more stable intermediate peptide.
Semax is well known for its absence of hormonal effects and neurological effects. In the medical field Semax has been incredibly useful because of its neurogenic and neuroprotective properties. In other words, Semax rapidly and efficiently activates serotogenic and dopaminergic brain systems. Also, n-acetyl semax amidate possesses both antidepressant and anxiolytic properties which allow it to qualify as a potential treatment for ADHD and depression.
Strangely, the exact mechanism of n-acetyl semax amidate is not yet fully understood, and yet Semax is viewed as much more secure and safe than other stimulants, such as Ritalin, Ephedrine, and Adderall.
While n-acetyl aemax amidate is recommended for treating various psychological and mental conditions, it is best at improving cognitive brain activities, such as learning skills, communication ability, enhanced memory, and logical reasoning.
Semax can achieve its results since it is most active in the central nervous system where it handles some of the essential neurotransmitters such as acetylcholine, norepinephrine, dopamine, and serotonin. After taking semax, the user begins to realize advantages such as reduced anxiety, mood enhancement, mental clarity, enhanced retention, better focus, faster recall, and enhanced verbal fluency
Extensive research indicates that n-acetyl semax amidate is more efficient than other ordinary semax products.
N-Acetyl Semax Amidate solution:10ml/30mg
Primary ingredient: N-Acetyl Semax Amidate (Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2). Other ingredients: Deionized water.
Peptide purity: Greater than 98.0%
Shipping Conditions: Temperature controlled packaging
Use: Nasal spray
Use: Not for human consumtpion. For research only.
Dosage: The dosage for N-acetyl semax amidate varies depending on the intended purpose. For instance, when taken for nootropic purposes the suggested dosage per day is 0.25-1mg. The only acceptable methods of administering N-acetyl semax amidate are intranasal and sub-q administration. On the other hand, when used for psychological purposes the recommended dosage is one spray per nostril two times a day (0.1ml/300mcg per spray). When using this medication, it is advisable to use it for up to 14 days at a time followed by a two-week break before using again. 1 spray per nostril twice a day
Extensive research also indicates that N-acetyl semax amidate is more efficient than other ordinary semax products.
Side effects: The effects of N-acetyl semax amidate are different for each user. There are no known symptoms of withdrawal, addiction. or adverse effects as a result of interactions with other medications. N-acetyl semax amidate is non-toxic and appears to be safe. N-acetyl semax amidate also does not seem to have any effects on the body even after regular use and increased dosage. However, in any case, it is important to keep in mind the fact that N-acetyl semax amidate has a short history and is therefore still a new nootropic. This implies that caution is necessary regardless of how exceptionally safe the medication is said to be. Due to the lack of side effects even after increasing dosage, when you become comfortable with the base dosage, you can gradually increase the dose to achieve stronger and more enhanced effects. Medication tolerance does not occur with N-acetyl semax amidate so it is likely that you will never need to change your dose.
All our peptides have a purity of at least 98%, most higher than 99%. Peptides are susceptible to heat so our peptides are kept as lyophilised powder in temperature-controlled medical fridges until the time of packaging. Shipments are hand-delivered to the post office at specific times in order to avoid exposure to heat for long periods of time while in the care of postal services. This ensures that the peptide you receive is as pure as possible.
ATTENTION: This compound should be used for research purposes only. All chemical compounds have risks. Please consult your physician and understand the available research before consumption. This product is not intended to diagnose, treat, cure, or prevent any disease.
This stuff truly rocks. Those interested will be put on preorder status and when you complete invoice we will formulate for you and ship 🚢 or you can obtain the raw powder and then put into the active basteriosteric sterilized water yourself and either use as drops ☔️ or sprayer and even subQ injection in fat thighs or buttocks.
“You know when you are on it and you feel better when you are on it. But you have control of your thoughts and can steer them how you want “
Semax is a heptapeptide, synthetic of an adrenocorticotropic hormone. It is a quintessential smart drug in that it fires up cognition as opposed to wakefulness, focus or motivation. So it will help you work smarter as opposed to harder, which sometimes is exactly what we need.
N-acetyl Semax 10ml spray. 98.73% purity (Copy)
What is n-acetyl Semax nasal spray?
N-acetyl Semax nasal spray is a powerful nootropic drug prescribed in Russia and Eastern Europe for cognitive improvement and balancing the immune system (not to be confused with acetyl l-tyrosine, or n-acetylcysteine). It is used throughout the world and in the US to improve learning, memory, focus, motivation, and resilience to stress.
N-acetyl Semax nasal spray effects:
- Enhances cognitive performance
- Boosts memory
- Balances immune system
- Fights chronic stress
- Improves peptic ulcer
- Treats ADHD
When you buy n-acetyl Semax nasal spray from limitlesslifenootropics.com, you get the highest purity nasal spray. Spray bottle will be included. Upon receipt, pour solution from the spray bottle into the amber container containing peptide, shake gently and let dissolve. This should take around 30 seconds. Then transfer back into the spray bottle and immediately refrigerate. Product should remain in refrigerator when not in use.
Contents: N-Acetyl Semax, Verified by HPLC to exceed 98.73% purity.
N-actetyl Semax nasal spray Overview
N-acetyl Semax nasal spray is a drug prescribed in Russia for its nootropic, restorative, and brain-protecting properties. It is used worldwide for cognitive enhancement and is unscheduled in the US. Semax is an analogue of adrenocorticotropic hormone, a 7 amino acid peptide, used medically for stroke, memory loss, brain injury, dementias, ADHD, and depression. It is also used by healthy people for cognitive enhancement, antidepressant action, anxiolytic effect, resilience to chronic stress, and general performance-enhancement. It protects the brain from the negative effects of chronic stressors by elevating BDNF neurotransmission and affecting dopamine and serotonin function. It is also reported to possibly be a partial agonist or antagonist of melanocortin receptors. Like related peptide Selank, Semax nootropic effect reduces the breakdown of important enkephalins which bind to opioid receptors.
Status of n-acetyl Semax nasal spray
N-acetyl Semax nasal spray is a medication in Russia and Eastern Europe for stroke and other types of brain injury. In the US, it is an unregulated substance. It is generally used as a cognitive enhancer like noopept, adrafinil, and other nootropics.
N-acetyl Semax nasal spray Side Effects
N-acetyl Semax nasal spray is thought to be very well-tolerated with few reports of adverse reactions.
- Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats.
- Changes in Sympathetic Innervation of Rat Caudal Artery in Experimental Myocardial Infarction. Effect of Semax Peptide.
- Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties.
- Semax prevents learning and memory inhibition by heavy metals.
- [EFFECT OF PEPTIDE SEMAX ON SYNAPTIC ACTIVITY AND SHORT-TERM PLASTICITY OF GLUTAMATERGIC SYNAPSES OF CO-CULTURED DORSAL ROOT GANGLION AND DORSAL HORN NEURONS].
- The action of the peptide drug Semax on the currents of AMPA receptors of rat cerebellar Purkinje cells.
- [Opposite Semax influence on conditioning and functional disturbances of avoidance responses in rats].
- The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.
- Heptapeptide semax attenuates the effects of chronic unpredictable stress in rats.
- [The effect of semax and its C-end peptide PGP on Vegfa gene expression in the rat brain during incomplete global ischemia].
- Study of proteolysis of Semax analogues with different N-terminal amino acids by carboxypeptidases.
- Semax corrects brain dysfunction caused by prenatal introduction of valproic acid.
- Semax prevents functional impairments of avoidance response in rats.
- Antistress effect of Semax in the course of recovery of spleen lymphoid structures after the stress in rats with different behavioral activity.
- Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain.
- Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.
- [Effect of semax and mexidol on brain ischemia models in rats].
- Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity.
- Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax.
- [Study of the efficacy of semax in global cerebral ischemia in vivo].
Claims from users (anecdotal)
Users report that using n-acetyl Semax nasal spray produces nearly instant clarity and focus of mind and relieves brain fog. A clarity of thought and stress resilience lasts several hours and allows the user to remain motivated while working on tasks for extended periods. A mood boost is often reported by users.
Disclaimer: This product is sold as a pure compound for research purposes only and is not intended for use as a dietary supplement. Please refer to our terms and conditions for purchase.
This product has not been evaluated by the FDA and is not intended to diagnose, cure, or prevent any disease.
Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.
This article is mostly going to focus on decoding what the human studies are saying about Semax and how this squares up with the anecdotal experiences of Biohackers online. For more of my own personal experiences, thoughts, and comparisons please see the written and video reviews in the sidebar.
It's been studied worldwide and has been the subject of about 30 articles of human research in the past 10 years that can be found on Pubmed which is relatively small compared to some cognitive enhancers like Piracetam has over 600 articles of human research.
Probably the most unique feature of Semax is that you take it nasally as opposed to orally as capsule or powder like most Nootropics. Absorption through the olfactory cavity is a much more direct channel to the brain than oral absorption, as anyone who has ever done a line in the bathroom has discovered. A few minutes after depositing drops in your nostrils you'll notice a heightened sense of focus and a little bit of a cool neurotransmitter rush.
A Californian Biohacker reported
"I agree whole-heartedly with the other member that said there is an almost instant feeling of clarity or clear-headedness. It seems to have a stimulatory and mood elevating effect."
One of the most distinctive features of Semax to western Biohackers is the Cyrillic text on its bottle and packaging. It's mainly produced and used in Russia and Ukraine (westerners for some reason are fond of the saying the Ukraine but you're actually not supposed to say it that way - you don't say the Germany or the Canada - at least according to my Ukrainian friends) although there's now a few reputable North American sources of this Slavic molecule.
I read at least several dozen Biohacker reports about Semax and the word that I kept seeing was clarity. Outside of the clinical trials where it is used as a treatment, the effect it seems to imbue consistently is clarity. It imbues a headspace of higher consciousness and maybe an enabler of good decisions. This pseudo-spiritual property is probably due to its anxiolytic property that tempers stress response and reactivity.
A Biohacker taking subcutaneous injections of it reported
"The biggest improvements I've noticed is on how clear my mind stays all day long and how I'm not spacey or anything after a night of smoking. Its extremely clear. I've noticed huge improvements in clarity of mind before on other noots but nothing like this. I'm also alert throughout the day unless I'm caught up in my own thoughts. Learning seems to have improved slightly and believe me I've been using it to my advantage everyday with programming and other hobby's I have."
Another Biohacker agreed
"Overall I feel that SEMAX gives one a really clear headspace; however, this has been hard to judge since I have had to pull two all-nighters this week. That being said, this does wonders for keeping one functional during sleep deprivation, and it also seems to be pretty potent in regards to anxiety"
It's frequently reported as subtle, don't expect it to be highly stimulating like Piracetam, Modafinil, Nicotine or other drugs that you put in your nose. Its effect on long term memory is not exactly instantaneous, it requires days or weeks of dosing to have a real effect on your long term memory, one Londoner reported
"I understand that some of you guys might be disappointed about Semax. You will probably not feel any effect straight after the administration (unless it's 1% solution or you are very sensitive)"
It's very important to take it for a reasonable period of time, otherwise, the effect will be minimal.
From a 2007 study of 27 Russian patients with motor neuron disease
However, 1% semax significantly improves the total estimate of life quality due to the improvement of emotional state and motivation in [motor neuron disease] patients with the maximal effect on day 10.
The study clarifies that it did not make much of a difference in healing the motor neuron disease itself it did markedly improve people's outlook on the significant challenge of overcoming their affliction.
However, the study doesn't clarify if it was double, blind placebo controlled nor does it disclose the funding source or institution that conducted it. So there's some reason for skepticism but I feel the study does have some relevance because so many anecdotal accounts confirm the effect on quality of life.
One Biohacker, a student at an elite university, reported
"Semax works slowly and progressively but the gains are permanent. You memorize faster and more information you understand concepts and ideas faster, you read faster, your overall thinking processes are enhanced. That's why i keep saying it is excellent. I have a lot of experience with cerebrolysin and i can say the results of semax are comparable with cerebrolysin's...
As i said before, it works slowly, but progressively. You will need 2 or 3 days and intense study to start noticing intelligence improvements. ( reading faster, understanding with less effort, etc, etc)"
Another Biohacker in New Jersey reported
"The effects that I subjectively felt included a level of calmness and mental clarity that I have yet to experience since treatment, as well as a slight increase in mental processing speed and memory recall. Overall it was the most powerful nootropic I have tried yet."
A European Biohacker on Longecity very articulately explained the connection between long term memory and Semax
"Memory is largely handled and processed at a brain structure called the hippocampus. In order for it to process data (to be memorized) it has to receive data from the sensory organs, vision, hearing, touch, smell etc. This data is transmitted along nerve fibers which in reality are neurons connected end to end with the understanding that on end of a long extension of one neuron (the axon) connects with a short extension of the next neuron (the dendrite) all these extensions originate from the body of the neuron (brain cell).
What complicates matters is that these data are in the form of electrical impulses and that the connection (called a synapse) is not 100%, i.e there is a GAP between the axon and the dendrite. The latter problem is solved by a substance called: neurotransmitters. The are expressed at the gap (called synaptic cleft) so the signal can traverse the gap assisted by this neurotransmitter substance. Examples of neurotransmitters are acetylcholine, serotonine etc . For a memory to be recorded as long term memory, the signal has to pass frequently, much like if you pass through a lawn frequently you will leave a trail of dead grass. This requires synaptic strengthening.
How is this achieved. We got to delve deeper here. Neurotransmitters work by coupling with receptors and thereby transfer the signal on so to say. To strengthen the synaptic passing of the signal we need more receptors and or more synapses. The formation of new synapses is called synaptogenesis. How is this acieved? Well receptors as well as synapses being constructed mainly of protein, we would require protein synthesis, the production of protein which is done by the cell itself (in-house factory). In the process of protein synthesis a factor is needed, its called Brain Derived Neurotrophic Factor (BDNF) for short.
This is where SEMAX comes into the picture, Semax increases the mRNA for BDNF production 500% (five-fold). mRNA or messenger Ribo Nucleic Acid is the molecule that reads the DNA code of the gene that is responsible for BDNF generation. In analogy if you increase your order five-fold at a restaurant for hamburger, you get 5 hamburgers. Boosting synaptic strengthening boosts memory formation long term. That Semax boosts BDNF production is proven in humans suffering from stroke on 160 patients in a double blind controlled trial..."
He went on to relate some more personal experiences
"Personal experience, if you are looking for a rush or hyped up state: Forget it.
If it did, it would be a stimulant and that you don't want. What you do get is : ability to take on increased mental loads without feeling like a burnt-out candle. When you read you'll find you retain content much easier, faster and more. I found that after a days work when I start working on private projects like writing a book, I find that I hit the train of thought on the subject much easier, find the correct words to reflect what I want to say quicker. I read longer because it doesn't tire me like before Semax...
The effect is subtle and becomes apparent gradually, it takes a couple of days...
My personal take is that you can't put a price on your mental prowess or quality of life. Also on life itself for that matter."
From a 2010 paper out of Institute of Molecular Genetics in Moscow
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) gene expression in rat brain and retina was analyzed by real-time polymerase chain reaction. It was revealed that after Semax administration the multidirectional activation of the expression of the genes under investigation in the hippocampus, frontal cortex, and retina was observed. The expression of both neurotrophin genes was decreased in rat hippocampus and retina 20 min after Semax administration and was increased in the frontal cortex. The expression levels of [Nerve growth factor] remained practically constant in the retina at the initial stage, whereas the expression levels of BDNF were significantly increased 90 min after Semax administration.
Just a single 2006 Moscow study addresses its effect on cognition
Semax-treated animals showed a distinct increase in the number of conditioned avoidance reactions. We suggest that Semax affects cognitive brain functions by modulating the expression and the activation of the hippocampal BDNF/trkB system.
A Canadian Biohacker taking 500mcg daily reported
"So far the effects are very good: it is very subtle but assist a lot in mental tasks, increase resistance to stress and fatigue and helps with general learning capabilities. I ranked those aspects everyday in my journal and there has been an increase accross the board on those measures.
Also, my working memory has improved as tested by N-Back... I'm a little more fluent when I write papers (I'm a researcher in my university) but nothing grandiose like when using Piracetam."
As the Canadian said if cognition is your priority you will likely do better with the Racetams.
The evidence of it combating fatigue or tiredness is not found in studies but a few Biohackers report a helpful effect. One user reported
"Only on the first few doses I noticed the stimulant like properties. It wasn't like adderall or caffeine or anything but I just felt awake and alert. I had enough energy to last all day and then some without any feeling of too much energy or being overwhelmed by the energy. Even on my weekend off I didn't notice a drop in energy levels. Along with better energy levels it also seemed that any fatigue I had vanished. I wasn't really fatigued at all before Semax but I noticed whatever fatigue I did have was gone."
From a 2007 Taiwanese paper on treating ADHD and Rett Syndrome
[Semax] has been found to stimulate memory and attention in rodents and humans after intranasal application...
In addition, Semax could improve selective attention and modulate brain development. Since ADHD is likely to be a neurodevelopmental disorder with disturbance in dopamine and BDNF function, it is proposed in this paper that Semax may have good therapeutic potential in ADHD. Furthermore, increased BDNF activity is found to improve Rett syndrome, a severe neurodevelopmental disorder
Another Russian study suggested that it repairs or optimizes the optic nerve.
Addition of semax to therapeutic complex in patients with diseases of the optic nerve had a favorable impact on the intensity and rate of recovery and improved the visual functions. Semax effectively protected nervous tissue from aftereffects of injury, particularly during the acute stage of optic nerve disease: it stimulated positive changes in the clinical picture, which were evaluated by improvement of visual acuity, extension of the total visual field, increase in the electric sensitivity and conductivity of the optic nerve, and improvement of color vision.
A 2012 study of 114 Russian's concluded
The most pronounced and long-standing (up to 12 months) positive effect on the visual function was documented in the main group.
A very few studies draw a connection between immunomodulatory properties and Semax, but this seems to be limited to how immunomodulation affects ischemic stroke.
Browsing the biohacker reports I could not find substantial evidence that had a desirable effect on the immune system; nobody reporting that it kept them from getting sick or helped appreciably with their autoimmune disorders.
I won't be trading it anytime soon for Eleuthero or Immune 26 as my go-to Immune Biohacking supplement.
From the abstract, that was translated from an older Russian human study
A combined clinical-electrophysiologic study revealed its high efficiency in acute ischemic stroke. A clinical trial was performed of immunobiochemical mechanisms of neuroprotective properties of Semax in acute period of ischemic stroke.
But again this study was on ischemic stroke, so if you don't have a problem with strokes you probably should not expect many benefits.
According to several science writers, this is another Nootropic with supposedly a mysterious mechanism of action. Likely, this is due to limited human research. However, there are a couple of mechanisms that we know about from animal studies
- It antagonizes the action of the melanocortin receptor.
- It also promotes the expression of brain-derived neurotrophic factor and signaling receptor TrkB in the hippocampus.
- It quickly energizes dopaminergic and serotoninergic brain systems.
- It enhances locomotor behavior elicited by D-amphetamine.
0.1% vs 1%
There are two main versions of Semax that vary quite a bit in concentration. One Biohacker reported
"I've used both Semax 1% and .1% several times.
The 1% was much more noticeable at first. It produced a heightened sense of smell, and slightly better verbal fluency. I recall the days I have taken it extremely well.
The .1% was less noticable but it functions just the same as a nootropic. I had excellent memory. It paired well with Phelypiracetam OR nicotine. I could remember vocabulary terms, and concepts with ease.
With the .1%, I redosed multiple times throughout the day, it probably is more effective than using the 1% just once a day."
However, that's the only Biohacker report I could find that indicated that there's much of an effect difference between 0.1% and 1%.
Semax from RUPharma
Comin' straight outta Moscow! This is the real deal. This is the Semax I did my Biohacker report on, my only issue with it is that the little vial is only a 1-2 week supply.
Semax from Limitless Life Nootropics
In an act of egregious Biohacker cultural appropriation, Ceretropic in the USA has begun producing and distributing pharmaceutical grade Semax. They offer multiple options including a powdered Semax that you have to mix yourself in Bacteriostatic water, if you don't mind doing a little mixology in your kitchen this seems like the best value for long term Semax usage. Also, they offer cold storage shipping, which is kind of important.
N-Acetyl Semax Amidate
It seems to me that this is the Mercedez-Benz of Semax versions. Biohackers seem to agree that it's more potent.
One user, a former meth addict reported
"The NA SEMAX Amidate I am using seems like it it beginning to repair my memory. My memory is ten times better than it was before, my priorities are reinforced in my mind every day, but not to an annoying extent, I just get things done plain and simple. Social anxiety is %100 non-existent, fluidity of my conversations with my co-workers and friends is exquisite. I am also beginning to try new social activities.
Still going daily 2 sprays, 1 per nostril, every day when I wake up of the 100mcg SEMAX Amidate. I forgot to mention that my sleep / wake pattern has improved vastly, not sporadic anymore. Clear - headed all day is the way to go."
It has an effect lasting 4-6 hours although some Biohackers report longer, up to 20 hours.
For some, it only produces a wow effect after a second dose
"Waited two hours then dosed another 200mcg with an additional cup of coffee and that's when the magic happened. Mental fatigue vanished, excellent boosts in alertness and clarity without the anxiousness and worsening of my ADD symptoms I often get from other noots like racetams. The effects were apparent for roughly 9 hours and I experienced a gradual, peaceful comedown instead of a crash. It's now 12 hours since the second dose and my thoughts are still clear, but I think I'll be able to sleep fine."
If you're taking it nasally, as most people do, each dose will be one to two drops per nostril.
Episodic vs Habitual Use
The human research and Biohacker reports indicate that the beneficial effects on memory via BDNF come after weeks of consistent dosing. However, not everyone is going to be able to afford that, it's also beneficial if used episodically as a focus and cognition enhancer.
One experienced user recommended
"....my advice to you for effective use would be to use it as needed but dose multiple times in the same day. If I had unlimited funds at my disposal, this would be my approach, use it on days when I need it, multiple times within that day. The days in which I have used Semax multiple times, it seemed to produce the best nootropic effects when dosed multiple times (better recall, clearer thoughts, and as some have mentioned 'feeling oxygenated')"
Cold storage is important, store it in your refrigerator. The Semax peptides will break down in water if stored at room temperature. This presents a bit of a concern with shipping, if possible you want to go with climate-controlled storage (yes this is a Nootropic that demands pampering). So I can imagine that if you ordered Semax during the summertime it may sit in hot trucks or warehouses for hours or days and it may not work as advertised. If you're buying your Semax from a pharmacy and it's not cold don't buy it.
However, it does seem to work pretty consistently. I did not come across many Biohacker reports of it being totally useless, so I would not be really concerned about this. All the vendors offer guarantees so if it doesn't work as advertised you can at least get a replacement.
Some opt to take Semax directly in their bloodstream.
- This is a safe way to take it provided that you mix it with Bacteriostatic water.
- You inject into a muscle, not a vein (which should make you feel like less of a junky).
- You want to cycle injection sites.
Will vary based upon the concentration. However, most people will be taking it nasally in the liquid form.
1-2 drops in each nostril 2 times a day (morning and afternoon). 1 vial lasts for about 7-14 days.
2-4 drops in each nostril 3-4 times a day (morning and afternoon) depending on the severity of stroke or illness.
One Biohacker used it for over 6 months and reported meticulously on its subjective effects, he concluded
"Over the cycle, I noticed a drastic improvement in clarity of thoughts and productivity. It is very subtle but you end up the day and looking back, you realize "sh*t got done!". I can safely say that many aspects of my life have improved during that time, in terms of cognition for sure but also in general sociability, reduction in stress level, I interact more with my colleagues, my wife and my kids.
I've used SEMAX alone as I was tired of "stacking" questionable chemicals and frankly, I don't feel the need to add anything else to it. Sometimes, I need to stay awake for far longer than I should since my line of work as crazy deadline and is very competitive so I do indulge in the modafinil or phenidate once a month or so and again, SEMAX seems to make the recovery process much easier."
At least a few Biohackers reported quitting their other Nootropics
"So far semax has been the most subtle but most efficient nootropic I've ever taken and I've tried a lot. What's even better is that I'm getting these effects from just the semax alone. But I have to say again, even though I'm getting all these effects, they are very subtle. Its not that I can't notice them but the improvements are becoming more noticeable everyday."
"Semax is one of my favorite nootropics. I said this before, and I'll mention it now, there is a feeling of clearheadedness I get almost immediately after dosing. Whenever I conversed whilst on semax, I had my thoughts collected better and and my vocabulary seemed more extravagant. I recall most of my moments on Semax remarkably well. I've used it to study pages of material in combination with phenlypiracetam or nicotine. The recall of the material studied worked well. Possible increase of motivation.
There are two periods of effects. Immediately after taking it and one that persists for over a day. The lasting effect can be attributed to an increase of BDNF."
A veteran Biohacker in London reported
"I have been taking Semax daily for a while now. In my opinion it is amazing nootropic. My memory has improved a lot, verbal skills are much better, mood is very stable and I am able to stay concentrated on any task much longer.
When I say that my memory has improved, I mean it has improved significantly. My colleagues have noticed that as well.
For example I can now remember most of the roads in London. I don't need my satnav anymore. Without semax I had to force my self to concentrate on every road, sign and name, otherwise I would not remember anything. Surprisingly I don't have to do this anymore, I remember everything naturally."
Perusing the anecdotal reports the side effects are pretty benign. About 15% of the users reported undesirable effects...
- Lack of motivation.
- Tiredness, slowness or lethargy.
- Irritability or moodiness.
Nothing serious. I could not find any cases of catastrophic overdose. The worst overdose case I could find was this guy who just got a major head rush, had an anxiety attack, went for a jog and then needed to take a bath.
Like I said it can have a nearly instant effect, pharmacologically this is an attribute of addictive drugs however, I came across virtual no cases of people developing addictions to it. This stuff seems to be safer than Ritalin, caffeine or Kratom.
From a Russian study of 187 patients
Semax treatment resulted in significant clinical improvement, stabilization of the disease progress and reduced a risk of stroke and transitory ischemic attacks in the disease course. The drug is featured by minor percent of side-effects and is well tolerated by patients, including those of older age groups.
As the safety profile is extremely good, the LD50 (the dose at which 50% of the test animals die) is undeterminable. This means that in spite of increasing the dose HUNDREDS of times the therapeutic dose NONE of the animals died. Hence you find that the dosage for every indication is quite flexible.
Is another psychoactive peptide developed by the Russian Institute of Molecular Genetics. Biohackers commonly combine the two. It's the one Semax cofactor that is supported by the published scientific research. An American Biohacker reported
"I had stacked it with selank a few days back, and took a very small dose of ritalin (2.5mg), and went on the most productive 5 hours I had in the last year."
"By the way, Phenotropil works wonders when I take it with Semax. Has anyone experienced that or it's just me?"
No studies have evaluated the two together but a number of Biohackers report them as being a brilliant combination.
It potentiates D-amphetamine. Several Biohackers stacked it with amphetamines like Ritalin and reported that it was overstimulating.
Over the course of researching and writing over fifty of these meta-analysis articles, I've read many thousands of Biohacker reports. With Semax, more than any other Nootropic ingredient I've researched, I kept coming across Biohackers saying that it's the best smart drug they've ever tried. It is particularly spoken high of in combination with Phenylpiracetam, which is debatably the best Racetam, a true smart drug.
For the risk-averse, on Pubmed, I could only find three clinical trials done and none of them were recent. So it's a little higher risk Nootropic, if you have a lower risk tolerance as Biohacker, like my friend Justin of Longecity, stick to the Adaptogens and Racetams.
You would expect the 1% to be a 10X better Nootropic than the .1% but none of the Biohacker reports indicate that. So I would recommend (at least the first time you try it) going with the .1% solution and spending the money you save on its cofactors.
If you're a new Biohacker or a budget Biohacker (a Biohacker ballin' on a budget?) Semax is probably not for you but if you're an experienced Biohacker with some money to spend on taking your cognition to the next level a combination of Semax+Phenyl might really be your own NZT-48.
If I were going to spend my own money on Semax I would go with the powdered N-Acetyl Semax Amidate, mix it myself with Bacteriostatic water and stack it with its cofactors.
I researched Semax thoroughly for my detailed meta-analysis and there's one reason why Biohackers should consider Semax. With Semax, more than any other Nootropic ingredient I've researched, I kept coming across Biohackers saying that it's the best smart drug they've ever tried.
If there's one thing you should expect in the short term and long term from Semax it's clarity of mind. This pseudo-spiritual property is probably due to its anxiolytic property that tempers stress response and reactivity.
On-label indications for Semax 0.1%
- Increasing attention during repetitive and monotonous tasks
- Increasing intellectual capacity in extreme circumstances
- Alleviating the effects of cerebrovascular diseases
On-label indications for Semax 1%
- Faster recovery after strokes
- Alleviation of migraines
- Transient ischemic attacks
Semax has a notable effect on those suffering from debilitating stress and depression. At least one study has shown that (for those suffering from mental illness, at least) it had a calming, sedative effect that reduced many of their anxiety-related issues. A Redditor articulated why Semax (especially in combination with Selank) is such an effective antidepressant:
First, Semax, holds the key to treat inflammation that causes depression at the source: the immune system. Semax is a synthetic analogue of ACTH (Adrenocorticotropic hormone) from Russian that most people use for stimulation and increasing mental capacity and whatnot. However, a closer look at Semax reveals a unique potential as a break through treatment for depression. ACTH in the body stimulates cortisol, the stress hormone, that suppresses the immune system. Therefore, Semax isn't just an anti-inflammatory drug that new scientific studies are focusing on for treatment in depression but a drug that can stop the inflammation at the source: the immune system. In addition, Semax increases both serotonin and dopamine in the brain, so it fights depression on two fronts, the chemical imbalance, which is only part of the picture, and the inflammation.
Next, Selank offers another breakthrough treatment for depression with more focus on anxiety. Selank is a synthetic analogue of tuftsin. Tuftsin in the body is a enzyme produced in the spleen that modulates the immune system. Tuftsin has been proposed as a possible treatment for autoimmune disorders for this reason. Back to the point, Selank modulates the immune system and directly affects T helper cells cytokines, the same culprits that cause the inflammation present in depression and anxiety. Like its brother Semax, Selank also increases serotonin in the brain. In clinical trials, Selank demonstrated as good if not better anxiolytic effects as benzos but without the addiction and side effects. Thus, Selank offers a likewise benefit for mental illness patients.
Semax works in a unique way to enable Neuroplasticity, the capacity of our brains to grow new brain cells and effectively form new memories. Research has shown it promotes brain-derived neurotrophic factor and nerve growth factor which has a profound positive effect on learning capabilities. This is not an immediate effect though, it requires several weeks or months of dosing.
Mechanism of Action
In addition to stimulating the central nervous system (enhancing energy and metabolism) it works to modulate receptors for various brain chemicals: acetylcholine, dopamine, serotonin, adenosine, and histamine. This results in the mental boost associated with the drug and allows users to perform brain tasks with increased vigor, clarity, and efficiency.
Usage and Dosage
- Take 2-4 drops twice daily. So one or two drops in each nostril, twice a day.
- Cold storage is important. Leave it in your refrigerator.